Mineralys Therapeutics
via Greenhouse
Executive Director, Clinical Development
This is the employer's own posting, not a copy on a job board.
What we know
Is it still open?
Confirmed still open
Last checked 1d ago — checked against the employer's own applicant tracking system, which is the company answering directly.
We re-read the employer's own applicant tracking system and the posting was still there. That is the company answering directly.
How old is it?
Posted 146d ago
The date the source published, not the day we noticed it (2026-04-21). Last seen at its source just now.
Is it remote?
US Remote
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Who may apply?
United States
The description states no restriction of its own. This is the source's own tag.
Pay
$340k–370k/yr
Read out of the job description by us, not from a structured field. Shown in the posting's own currency and period; we never convert.
Skills named in the ad
Recognised terms only, from a fixed vocabulary — this is what CV matching compares against.
Carried by 1 source
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greenhouse employer's own board first seen 12d ago · last seen just now
The listing
“Mineralys Therapeutics is a clinical-stage biopharmaceutical company focused on developing medicines to target hypertension and related comorbidities such as chronic kidney disease (CKD), obstructive sleep apnea (OSA) and other diseases driven by dysregulated aldosterone. Its initial product candidate, lorundrostat, is a proprietary, orally administered, highly selective aldosterone synthase inhibitor. Mineralys is headquartered in Radnor, Pennsylvania. For more information, please visit https://mineralystx.com. Follow Mineralys on LinkedIn, Twitter and Bluesky”
Mineralys is a fully remote company.
Executive Director, Clinical Development
The Executive Director, Clinical Development will serve as the clinical lead for development program(s) and play a critical role in advancing pivotal studies, regulatory strategy, and submission readiness. This physician leader will provide medical and scientific oversight across the program lifecycle, from protocol design and study execution through data interpretation, regulatory interactions, and launch preparation.
This role requires a hands-on clinical development leader who thrives in a fast-paced biotech environment and can partner cross-functionally to drive high-quality execution with urgency.
Key Responsibilities:
Clinical Development Leadership
- Serve as the clinical lead for one or more clinical programs, with responsibility for clinical trial design, execution oversight, and delivery of key milestones.
- Lead development of clinical plans, protocols, amendments, , and related study documents.
- Provide medical oversight for Phase 2/3 and/or registrational studies, ensuring patient safety, data integrity, and operational excellence.
- Partner with Clinical Operations, Biostatistics, Data Management, Regulatory, and Safety to ensure efficient study execution and timely issue resolution.
- Drive study start-up, enrollment, interim analyses, database locks, topline results, and CSR delivery.
Medical Monitoring / Safety Oversight
- Serve as medical monitor for assigned studies, including review of eligibility, protocol deviations, safety signals, SAEs/AEs, and benefit-risk assessments.
- Collaborate with Pharmacovigilance on safety surveillance, signal detection, DSMB materials, and aggregate safety reporting.
- Support development of risk mitigation strategies and ensure patient safety remains central throughout program execution.
Regulatory / Submission Support
- Contribute to global regulatory strategy and interactions with health authorities (FDA, EMA, PMDA, etc.).
- Author and review clinical sections of regulatory documents, including briefing books, protocols, CSRs, IBs, and submission modules.
- Present clinical data and strategy to regulators, internal governance committees, and senior leadership.
Scientific / Cross-Functional Leadership
- Serve as the key clinical voice on cross-functional program teams.
- Partner with Translational Medicine, Biomarkers, Medical Affairs and Commercial to align development strategy with future launch needs.
- Support publication planning, congress presentations, and external scientific engagement.
- Build strong relationships with KOLs, investigators, and external experts.
Team / Culture Leadership
- Mentor internal team members and external consultants/CRO partners.
- Foster a culture of collaboration, accountability, urgency, and quality.
- Operate effectively in a lean biotech environment where flexibility and ownership are essential.
Experience and Qualifications:
- MD or equivalent medical degree required; board certification preferred in Internal Medicine, Cardiology, Nephrology, Endocrinology, or related field.
- 10+ years of industry clinical development experience, including significant late-stage / registrational trial leadership.
- Prior experience serving as medical monitor and clinical lead for Phase 2/3 studies.
- Proven experience with NDA / BLA submission support and health authority interactions.
- Strong understanding of GCP, ICH guidelines, safety reporting, and global clinical development processes.
- Demonstrated ability to lead cross-functional teams and influence without direct authority.
- Strong scientific communication and presentation skills.
- Experience in hypertension, cardiovascular, renal, or metabolic disease strongly preferred.
These positions are eligible for standard Company benefits including medical, dental, vision, time off and 401K, as well as participating in Mineralys incentive plans are contingent on achievement of personal and company performance. Actual compensation may vary from posted hiring range based on geographic location, work experience, education, and/or skill level.
US Salary Range: $340,000 - $370,000
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